Indentification of breast cancer subtypes sensitive to HCQ-induced autophagy inhibition
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چکیده
منابع مشابه
Identification of breast cancer cell subtypes sensitive to ATG4B inhibition
Autophagy, a lysosome-mediated degradation and recycling process, functions in advanced malignancies to promote cancer cell survival and contribute to cancer progression and drug resistance. While various autophagy inhibition strategies are under investigation for cancer treatment, corresponding patient selection criteria for these autophagy inhibitors need to be developed. Due to its central r...
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Autophagy is a protein and organelle degradation pathway that is involved in diverse diseases, including cancer. Recent evidence suggests that autophagy is a cell survival mechanism in tumor cells and that its inhibition, especially in combination with other therapy, could be beneficial but it remains unclear if all cancer cells behave the same way when autophagy is inhibited. We inhibited auto...
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Apigenin (4',5,7-trihydroxyflavone) is a member of the flavone subclass of flavonoids present in fruits and vegetables. The involvement of autophagy in the apigenin-induced apoptotic death of human breast cancer cells was investigated. Cell proliferation and viability were assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and clonogenic assays. Flow cytometry, fluor...
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AIM Sulforaphane (SFN), which is present in cruciferous vegetables, induces growth arrest and/or cell death in cancer of various organs. The involvement of autophagy in the SFN-induced apoptotic death of human breast cancer cells was investigated. MATERIALS AND METHODS Cell proliferation and viability was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and...
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Introduction: Early diagnosis of breast cancer and the identification of effective genes are important issues in the treatment and survival of the patients. Gene expression data obtained using DNA microarray in combination with machine learning algorithms can provide new and intelligent methods for diagnosis of breast cancer. Methods: Data on the expression of 9216 genes from 84 patients across...
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ژورنال
عنوان ژورنال: Pathology - Research and Practice
سال: 2019
ISSN: 0344-0338
DOI: 10.1016/j.prp.2019.152609